A recently discovered cell-to-cell communication pathway may provide the missing puzzle piece for more precise drug delivery. It has emerged that almost all the cells within our body can establish links to neighboring as well as distant cells by the release of tiny “balloons”, termed extracellular vesicles (EVs). The discovery that these EVs, in particular exosomes, are functional shuttles of signaling molecules, led to the idea that they could represent ideal nanoscale candidates for drug delivery systems of modern day pharmaceuticals.
Despite major breakthroughs in the identification of new promising drug candidates, translating these findings into the clinic is often hampered by challenges in delivering an efficacious drug dosage to the site of the disease. In an effort to address this challenge, researchers are deciphering the natural communication pathways in the human body, specifically how cells broadcast signals to distant recipient cells.
However this notion is linked to a major challenge: Transforming extracellular vesicles from natural message couriers to drug carriers requires efficient vesicle engineering capacity.
The Hybridosome™ platform, under development by Anjarium Biosciences, addresses this key bottleneck in EV engineering. Irrespective of the EV origin, the Hybridosome™ approach allows comprehensive functionalization by
- Addition of various therapeutic and diagnostic cargoes into the lumen and
- The modification of vesicle surface properties (i.e. targeting ligands) creating the potential for additional specificity and improved biodistribution.
By enabling rational design of bespoke EV-based carriers, the platform is powerful with widespread applicability for targeted delivery of nucleic acids, small molecules and macromolecules in ex vivo applications and in vivo indications with high unmet medical need.
We welcome opportunities to collaborate with biopharmaceutical companies that wish to take advantage of our Hybridosome™ technology.
Cell to cell communication is essential for all multicellular organisms. Aside from exchanging information through the secretion of soluble factors or by direct interaction, cells also naturally release membrane-derived micro- and nano-sized vesicles that are shuttled to neighboring and/or distant cells. These extracellular vesicles (EVs) are secreted by almost all cells and can be found in the plasma as well as other bodily fluids. The secreted nanovesicles referred to as exosomes are between 30-150 nm in diameter originate within the cell. This biogenesis mechanism enables natural loading of their lumen with bioactive constituents such as nucleic acids. After release, the encapsulated cargo of these endogenous carriers is protected by the lipid bilayer, and upon interaction with the recipient cell may provoke functional and phenotypical changes. Moreover, EVs are enriched with proteins that participate in important biological functions including adhesion and membrane trafficking molecules. It has been proposed that these unique components allow exosomes to specifically interact with target cells and that this natural cargo delivery occurs in a non-random process.